24-004612

Submitted by fratecm on
Post Date/ Solicitation Issue Date
Closing Response Date
Proposed Award Date
Project Title
Synaptic Dynamics of Sensory Motor Integration
Contracting Office
National Institute of Mental Health (NIMH)

Contact Points

Primary Contract Specialist

Cheryl
Leone
cleone@mail.nih.gov

Secondary Contracting Officer

Dionne
Draper
dionne.draper@nih.gov
NAICS Code Number
541715
Research And Development in the Physical, Engineering, And Life Sciences (Except Nanotechnology and Biotechnology)
Small Business Size Standard
$1000
FPDS Classification Code
R499
Estimated Period of Performance
6 months
Competition Status
Brand Name Only
Vendor Name
Changquan Ye
Vendor Address
17516 Soper St.
Poolesville, MD 20837
Vendor Name
Dr. Changquan Ye
Address
17516 Soper St.
Poolesville, MD 20837
Single-Sole Source Determination
Dr. Changquan Ye is considered an international recognized expert utilizing electrophysiological tools and computational analysis methods using animal (mouse) models. With these models he is able to record different brain activity and motor behavior, a skill very few scientists possess. Dr. Ye received his Ph.D. from the Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, one of the best neuroscience institutes in China. Dr. Ye has also published numerous papers over his career. His papers have appeared in a variety of high-profile journals including Journal of Neuroscience and Neuron. Dr. Ye worked at NIDA, NIH as a special volunteer conducting electrophysiological recordings and data analysis in Dr. Morales’s lab in 2014. Dr. Ye is an expert who has strong experience in electrophysiological recording from rodents and in computational analysis on large neuronal and behavior datasets. Over the past years, my lab has consulted with Dr. Ye on data analysis and the interaction and collaboration has been successful.
His extensive research experience of sensorimotor integration using in vivo electrophysiology, broad knowledge on system neuroscience, and innovative computational analysis for rodent behavior and large neuronal data exclusively qualifies him for this work. In fact, there is no other researcher, in my opinion, that has this expertise over multiple domains.
Background/Description of Requirement

Statement of Need and Purpose:  The goal of the Unit on Functional Neural Circuits (UFNC) is to understand the fundamental principles and organization of neural circuits that enable cortical communication and support the computations of dynamic interactions between sensory and behavioral functions. The team investigates: 1) how different circuit motifs and diverse neuronal types interact to enable reciprocal interactions between internally generated and externally driven brain activity, and 2) how these interactions are established during development. The impairment of communications among different cortical areas often lead to psychiatric disorders. UFNC requires a leading authority working on recording brain activity and motor behavior under in vivo condition using electrophysiological tools and computational analysis methods using animal (mouse) model. UFNC requires that the consultant has expertise in technologies for electrophysiological recordings and computational skills of behavioral assessment and intervention, including naturalistic video and audio capture, telemetric physiological monitors, wireless accelerometry sensors, and digital video/facial recognition systems.

Background Information and Objective:  The overall goal of collaboration with the contractor is to continue to establish a system to conduct extracellular and intracellular electrophysiological recording from a mouse during sensorimotor behavior tasks and analysis protocols. This work provides a platform to examine complex neuronal activity during sensorimotor-related behavior at the level of synaptic resolution. The contractor has a leading role in all these projects, including overseeing the technical work of choosing hardware, overseeing the technical work of research fellows, data analysis, and writing of scientific reports. This acquisition aims to acquire a contractor to oversee the experimental protocol and data acquisition system of these methods to other members in the lab.

Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.